Living organisms can cope with disruption of homeostasis such as injury and disease to a certain degree. This results in restoration of steady state homeostasis, death of affected tissues or ultimate organismal death. The outcome depends on the type of insults, species of animals and maturation of tissues. While the process is well recognized, we still do not know the mechanisms defining responses to disruption of homeostasis in different organs and species. Our research focuses on two fundamental questions targeting major disruption of homeostasis in organisms:

  • How do animals repair tissues upon injury?
  • How does oncogenic stress by cancer affect animals?

To do this, we combine unrivaled genetics of the fruit fly, Drosophila melanogaster, with cell biology in zebrafish, Danio rerio, which are highly amenable to reverse genetics, live imaging and optogenetics.

1. 生物はどうやって傷に対応するか?
2. 癌は生物にどのような影響を与えるのか?